:root {
  --paper: #f4f6f7;
  --panel: #ffffff;
  --ink: #17212b;
  --muted: #5c6b78;
  --rule: #d5dbe0;
  --blue: #2c3e91;      /* Coomassie */
  --blue-soft: #e6e9f6;
  --red: #a8232f;       /* heme */
  --red-soft: #f6e4e5;
  --serif: "Spectral", Georgia, "Times New Roman", serif;
  --sans: "Atkinson Hyperlegible", system-ui, -apple-system, "Segoe UI", sans-serif;
  --mono: "JetBrains Mono", ui-monospace, "SFMono-Regular", Menlo, monospace;
  --measure: 72ch;
}
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0; background: var(--paper); color: var(--ink);
  font: 17px/1.55 var(--sans);
  padding-top: env(safe-area-inset-top, 0px); padding-bottom: env(safe-area-inset-bottom, 0px);
}
a { color: var(--blue); text-underline-offset: 2px; }
:focus-visible { outline: 3px solid var(--blue); outline-offset: 2px; border-radius: 2px; }
h1, h2, h3 { font-family: var(--serif); line-height: 1.15; margin: 0 0 .4em; }
h1 { font-size: clamp(2rem, 4.5vw, 3.1rem); font-weight: 700; }
h2 { font-size: 1.6rem; font-weight: 600; margin-top: 2.2rem; }
h3 { font-size: 1.15rem; font-weight: 600; }
p { max-width: var(--measure); }
code, .mono { font-family: var(--mono); font-size: .88em; }

.masthead {
  display: flex; justify-content: space-between; align-items: baseline; gap: 1rem;
  max-width: 1180px; margin: 0 auto; padding: 1.1rem 1.25rem .4rem;
}
.brand { font-family: var(--serif); font-weight: 700; font-size: 1.15rem; color: var(--ink); text-decoration: none; }
main { max-width: 1180px; margin: 0 auto; padding: 1rem 1.25rem 3rem; outline: none; }
.foot { max-width: 1180px; margin: 0 auto; padding: 1.5rem 1.25rem 2.5rem; color: var(--muted); font-size: .9rem; border-top: 1px solid var(--rule); }

/* ---- search ---------------------------------------------------------------- */
.hero { padding: 3.5rem 0 1.5rem; max-width: 820px; }
.hero p.lede { font-size: 1.15rem; color: var(--muted); }
.query {
  display: flex; gap: .75rem; align-items: stretch; margin-top: 1.8rem; flex-wrap: wrap;
}
.query input {
  flex: 1 1 320px; min-width: 0; font: 600 clamp(1.6rem, 4vw, 2.4rem)/1.2 var(--mono);
  letter-spacing: .02em; padding: .55rem .9rem; border: 2px solid var(--ink); border-radius: 6px;
  background: var(--panel); color: var(--ink);
}
.query input::placeholder { color: #aab4bd; }
button, .btn {
  font: 700 1rem var(--sans); padding: .75rem 1.2rem; border-radius: 6px; cursor: pointer;
  border: 2px solid var(--blue); background: var(--blue); color: #fff; text-decoration: none;
  display: inline-flex; align-items: center; gap: .4rem;
}
button.secondary, .btn.secondary { background: transparent; color: var(--blue); }
button:disabled { opacity: .5; cursor: progress; }
.examples { margin-top: .9rem; color: var(--muted); font-size: .95rem; }
.examples button { font: 600 .9rem var(--mono); padding: .2rem .55rem; border-width: 1px; background: transparent; color: var(--blue); margin: 0 .2rem .3rem 0; }
.mode { display: flex; gap: 1.5rem; margin-top: 1.2rem; flex-wrap: wrap; }
.mode label { display: flex; gap: .5rem; align-items: flex-start; max-width: 360px; cursor: pointer; }
.mode input { margin-top: .35rem; accent-color: var(--blue); }
.mode small { display: block; color: var(--muted); }

.matches { list-style: none; padding: 0; margin: 1.5rem 0 0; max-width: 820px; }
.matches li + li { border-top: 1px solid var(--rule); }
.matches button {
  all: unset; box-sizing: border-box; display: grid; grid-template-columns: 9rem 1fr auto; gap: 1rem;
  width: 100%; padding: .8rem .6rem; cursor: pointer; align-items: baseline;
}
.matches button:hover, .matches button:focus-visible { background: var(--blue-soft); }
.matches .sym { font: 700 1.1rem var(--mono); }
.matches .acc { color: var(--muted); font-family: var(--mono); font-size: .85rem; }

.notice { border-left: 4px solid var(--red); background: var(--red-soft); padding: .8rem 1rem; margin: 1rem 0; max-width: var(--measure); }
.notice.info { border-color: var(--blue); background: var(--blue-soft); }

/* ---- progress ---------------------------------------------------------------- */
.steps { list-style: none; padding: 0; margin: 2rem 0; max-width: 560px; counter-reset: s; }
.steps li { counter-increment: s; display: grid; grid-template-columns: 2.2rem 1fr; gap: .6rem; padding: .55rem 0; color: var(--muted); }
.steps li::before {
  content: counter(s); width: 1.8rem; height: 1.8rem; border-radius: 50%; border: 2px solid var(--rule);
  display: grid; place-items: center; font: 700 .85rem var(--sans);
}
.steps li.done { color: var(--ink); }
.steps li.done::before { content: "✓"; background: var(--blue); border-color: var(--blue); color: #fff; }
.steps li.active { color: var(--ink); font-weight: 700; }
.steps li.active::before { border-color: var(--blue); color: var(--blue); animation: pulse 1.4s ease-in-out infinite; }
.steps .msg { display: block; font-weight: 400; color: var(--muted); font-size: .92rem; }
@keyframes pulse { 50% { box-shadow: 0 0 0 6px var(--blue-soft); } }
@media (prefers-reduced-motion: reduce) { .steps li.active::before { animation: none; } }

/* ---- results ------------------------------------------------------------------ */
.result-head { padding: 2rem 0 .5rem; border-bottom: 2px solid var(--ink); }
.result-head .gene { font-family: var(--mono); }
.result-head .facts { display: flex; flex-wrap: wrap; gap: .3rem 1.6rem; color: var(--muted); margin-top: .4rem; }
.result-head .facts b { color: var(--ink); }

.story { display: grid; gap: 1.1rem; margin-top: 1.5rem; max-width: 860px; }
.story article { display: grid; grid-template-columns: 13rem 1fr; gap: 1.2rem; }
.story h3 { font-size: 1.05rem; margin: .1rem 0 0; }
.story p { margin: 0; }
.story .src { display: block; color: var(--muted); font-size: .85rem; margin-top: .25rem; }

.panel { background: var(--panel); border: 1px solid var(--rule); border-radius: 8px; padding: 1rem; }
.tree-tools { display: flex; flex-wrap: wrap; gap: .5rem 1.2rem; align-items: center; margin-bottom: .6rem; font-size: .95rem; }
.tree-tools label { display: inline-flex; gap: .35rem; align-items: center; cursor: pointer; }
.tree-tools button { padding: .35rem .7rem; font-size: .9rem; }
.tree-wrap { overflow-x: auto; }
.tree-wrap svg { display: block; }
.legend { display: flex; flex-wrap: wrap; gap: .3rem 1rem; font-size: .9rem; margin-top: .6rem; }
.legend span::before { content: ""; display: inline-block; width: .8rem; height: .8rem; border-radius: 2px; background: var(--c); margin-right: .35rem; vertical-align: -1px; }
.tree-note { color: var(--muted); font-size: .92rem; margin: .6rem 0 0; }

.table-wrap { overflow-x: auto; }
table { border-collapse: collapse; width: 100%; font-size: .95rem; }
th, td { text-align: left; padding: .5rem .6rem; border-bottom: 1px solid var(--rule); vertical-align: top; }
th { font-weight: 700; border-bottom: 2px solid var(--ink); white-space: nowrap; }
td.num { font-variant-numeric: tabular-nums; }
.res { font: 700 1rem var(--mono); color: var(--red); }
.flag { display: inline-block; font-size: .8rem; padding: .05rem .45rem; border-radius: 999px; background: var(--red-soft); color: var(--red); font-weight: 700; }
tr.expand td { background: #fafbfc; }
.slice { font: .82rem/1.35 var(--mono); border-collapse: collapse; width: auto; }
.slice td { padding: 0 .15rem; border: 0; white-space: nowrap; }
.slice td.lab { font-family: var(--sans); padding-right: .8rem; color: var(--muted); }
.slice td.aa { width: 1.05rem; text-align: center; }
.slice td.focus { outline: 2px solid var(--red); outline-offset: -1px; }
.aa-h { background: #dbe3f7; } .aa-p { background: #d9efdc; } .aa-c { background: #f6d9dc; }
.aa-a { background: #efe2f5; } .aa-g { background: #fbecc9; } .aa-y { background: #d6eff0; }

.cols { display: grid; grid-template-columns: repeat(auto-fit, minmax(300px, 1fr)); gap: 1.2rem 2rem; }
.cols ul { padding-left: 1.1rem; margin: .3rem 0; }
.downloads { display: flex; flex-wrap: wrap; gap: .5rem; }
.downloads a { font-size: .92rem; padding: .45rem .8rem; }
details summary { cursor: pointer; font-weight: 700; }

@media (max-width: 700px) {
  body { font-size: 16px; }
  .story article { grid-template-columns: 1fr; gap: .2rem; }
  .matches button { grid-template-columns: 1fr; gap: .1rem; }
}